The bioavailability of lorazepam is approximately 90%. Peak concentrations are attained two hours following oral administration. Its inhibitory action in the amygdala is beneficial in anxiety disorders, while its inhibitory activity in the cerebral cortex is beneficial in seizure disorders.Ībsorption: lorazepam is well absorbed after oral administration. This shift in chloride ions results in hyperpolarization and stabilization of the cellular plasma membrane. It enhances the inhibitory effects of GABA, which increases the conductance of chloride ions in the cell. Lorazepam binds to benzodiazepine receptors on the postsynaptic GABA-A ligand-gated chloride channel neuron at several sites within the central nervous system (CNS). Chemotherapy-associated anticipatory nausea and vomiting (adjunct or breakthrough).Rapid tranquilization of the agitated patient.Anesthesia premedication in adults to relieve anxiety or to produce sedation/amnesia.Short-term (4 months) relief of anxiety symptoms related to anxiety disorders. Lorazepam is also one of the few sedative-hypnotics with a relatively clean side effect profile. Lorazepam has common use as the sedative and anxiolytic of choice in the inpatient setting owing to its fast (1 to 3 minutes) onset of action when administered intravenously. It went on the market in the United States in 1977. Lorazepam is a benzodiazepine medication developed by DJ Richards.
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